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The Difference Between PRP and PRF

  • thilljensen
  • May 10
  • 2 min read

Updated: 4 hours ago

Differences Between PRP and PRF

Platelet-Rich Plasma (PRP)

  • Composition: PRP is a concentration of platelets in plasma, which includes a variety of growth factors and cytokines.

  • Preparation: PRP prepared by centrifuging whole blood combined with an anticoagulant to separate the plasma and platelets from red blood cells.

  • Action: PRP delivers a quick burst of signalling factors

  • Application: Commonly used for a quick refreshing appearance.

Platelet-Rich Fibrin (PRF)

  • Composition: PRF contains a higher concentration of fibrin along with platelets, leukocytes, and signalling factors, resulting in a more structured matrix.

  • Preparation: PRF is created through a slower centrifugation process that allows the formation of a fibrin matrix, which entraps platelets and signalling factors.

  • Action: PRF delivers an enmeshed fibrin matrix, which releases signalling factors more gradually over time.

  • Application: Commonly used to correct scars or deeper lines by supporting collagen production.

Benefits of PRP

  • Promotes superficial tissue regeneration.

  • Less inflammatory, quicker recovery, combating early superficial age-related changes.

  • Minimally invasive.

Benefits of PRF

  • Provides a natural scaffold at a deeper tissue level.

  • Releases signalling factors over an extended period, combating scar tissue and deeper, more advanced age-related changes, further supporting collagen production.

  • Minimally invasive.

Applications of PRP

  • Hair restoration/androgenic hair thinning

  • Larger scar revision areas

  • Acne scarring with resurfacing

  • Stretch marks

  • Skin texture and collagen stimulation over broader surfaces

  • Areas requiring multiple injection passes or larger treatment volumes

Applications of PRF

  • Under-eye rejuvenation

  • Thin or delicate skin areas

  • Fine lines and crepe-like skin

  • Facial volume support

  • Deeper facial folds

  • Localized scar tethering

  • Surgical scars requiring structural remodeling

  • Areas of fibrosis or poor circulation

Combination Approaches (Very Common)

  • PRP microneedling = broader collagen stimulation; plus

  • Injectable PRF = targeted support under eyes, scars, or folds

This allows rapid signalling from PRP and sustained remodeling from PRF. The two therapies are complementary rather than competitive.



 
 
 

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The information provided by Peak Performance Recovery Lab Inc. is for general educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. This clinic operates as a non-diagnostic, private clinic, and all therapies are provided under authorized prescriber orders or approved protocols in accordance with applicable regulatory standards. Services offered are not a substitute for care provided by your physician or specialist. You should consult your qualified healthcare provider regarding any medical condition or treatment decisions. Individual results may vary, and no guarantees are made regarding outcomes.

 

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